Transgendered  Soul
Science
Welcome to our Science Page.
Thank you for visiting the Transgendered Soul International Website!!

The Transgendered Soul (TGS)  gives only general information relating to transition for individuals with gender disphoria or Intersexed condition.  We are not responsible for
what the individual does with that information.  We do not suggest any results from the information provided here.  Our purpose is to offer resources and encouragement to
individuals suffering with these conditions in hopes of connecting them with resources useful to them and all aspects of their transition.  The TGS will be held harmless from any
results an individual gets from a provider or information located on this site.   TGS does not engage in the practice of medicine or psychology, is not a medical or psychological
authority, and does not claim medical or psychiatric knowledge. TGS recommends that you consult your own physician and psychologist regarding any course of  treatment or
medication.  There are links to other web sites in various places through out our web site. TGS is not responsible for the content of other websites reached from links on our
website.  Use of this site and its information constitutes an agreement to these terms.
On this page you will find information and links to help you in understanding what this condition is scientifically and how this
condition could have happened.  This page is not about blame, but understanding.  Always try to remember that what is most
important is how we deal with the situations that life brings to us.

What is this condition?
What do researchers think Transsexualism/Gender Identity Disorder is?  One idea gaining acceptance and scientific backing is
that the brains of transsexuals are actually wired for the opposite gender.  Specifically the central part of the bed nucleus of the
stria terminalis (BSTc).  See articles on brain differences below.

How does this condition occur?  
Simply put, all fetuses start out as female.  It is an individuals genetic code that tells the fetus to become male or not.  A
developing fetus goes through two specific (sex) hormonal washes.  The first is thought to differentiate the body in accordance
with the genetic code.  The second is thought to differentiate the brain.  It is believed, that if the washes are two different
hormones, or if one of the washes is lacking, then the body and brain may be programmed oppositely, one male, the other
female.  Any substance, condition or situation that alters the hormone washes may produce a transgendered child.  Examples
of things thought to contribute to hormone disturbances in fetuses include, stress, drugs, environmental hormones and medical
conditions.

Articles and Links

Brain Differences
Current Thinking Regarding the Etiology of Gender Disphoria - pdf
By Anne Vitale PhD.
http://www.avitale.com/MenuPage.html

Male-to-Female Transsexuals Have Female Neuron Numbers in a Limbic Nucleus - Abstract online
The Journal of Clinical Endocrinology & Metabolism Vol. 85, No. 5 2034-2041
http://jcem.endojournals.org/cgi/content/abstract/85/5/2034

A Sex Difference in the Human Brain and its Relation to Transsexuality - Article online
By J.-N. Zhou, M.A. Hofman, L.J. Gooren and D.F. Swaab
Reprint at:  The International Journal of Transgenderism
http://www.symposion.com/ijt/ijtc0106.htm


Drug Influences
DES, Definition of - online
DES - Diethylstilbestrol, the earliest synthetic (man-made) form of a hormone in the estrogen class.  DES was once widely
prescribed to prevent miscarriages and premature births. Its usage was standard practice in the 1950s and 1960s. Millions of
women received the drug.  Girls whose mothers were given DES during pregnancy ("DES daughters") were discovered to be
at increased risk for being born with malformations of the reproductive organs and to face elevated rates of infertility and
miscarriages themselves.  
http://www.medterms.com/script/main/art.asp?articlekey=13637

Pondering  the  Possible Connection Between DES and Mixed Gender Identity - pdf
By Leef Smith

Environmental Estrogens
Endocrinology and Environmental Estrogens - pdf
Environmental Estrogens are chemicals found around us that act like the female sex hormone, estrogen.  Estrogenic chemicals
may occur in nature or can be man-made.
The Endocrine Society
www.endo-society.org

That Feminine Touch - pdf
By J. Raloff 1994
Are men suffering from prenatal or childhood exposures to "hormonal" toxicants?


Medical Conditions
You've (Still) Got Male - pdf
A study finds boys with genital defects who are raised girls revert back to their original gender.

Polycyctic Ovary - pdf
A medical condition meaning many ovarian cycts.  The condition is accompanied by elevated levels of dehydroepiandrosterone
causing potentially causing masculinization.

Genetics
Sexual Identity Hard-Wired by Genetics - Study - pdf
(Article appeared in Reuters.)

Other links of interest:

Sexual behaviour in animals
Homosexual Activity Among Animals Stirs Debate - online
James Owen in London for National Geographic News, July 23, 2004
http://news.nationalgeographic.com/news/2004/07/0722_040722_gayanimal.html

List of animals displaying homosexual behavior - online
From Wikipedia, the free encyclopedia
http://en.wikipedia.org/wiki/List_of_animals_practicing_homosexual_behavior
Welcome to our Science Page
It seems that one of validations we need or want is scientific validation that this condition is "real" and
not a mental illness, a phase or a fad.